臺灣次世代基因定序檢測實作指引
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: obs-biomarker-min - JSON Representation

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{
  "resourceType" : "Observation",
  "id" : "obs-biomarker-min",
  "meta" : {
    "profile" : [
      🔗 "http://example.org/StructureDefinition/Observation-biomarker-twngs"
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation obs-biomarker-min</b></p><a name=\"obs-biomarker-min\"> </a><a name=\"hcobs-biomarker-min\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Observation-biomarker-twngs.html\">基因生物標記資訊-Observation Biomarker TWNGS</a></p></div><p><b>status</b>: Final</p><p><b>code</b>: <span title=\"Codes:{http://example.org/CodeSystem/genomic-observation-type-cs biomarker}\">Biomarker</span></p><p><b>subject</b>: <a href=\"Patient-pat-min.html\">王大明 Male, DoB: 2001-01-01 ( Medical record number\u00a0(use:\u00a0official,\u00a0))</a></p><p><b>effective</b>: 2024-01-01</p><p><b>note</b>: </p><blockquote><div><p>HRD (Homologous Recombination Deficiency)-high HLA LOH (Human Leukocyte Antigen Loss of Heterozygosity) -HLA-A loss</p>\n</div></blockquote><p><b>specimen</b>: <a href=\"Specimen-spe-bld-min.html\">Specimen: identifier = 123-4567; type = Bld</a></p><p><b>device</b>: <a href=\"Device-dev-min.html\">Device: modelNumber = HiSeq 4000 System</a></p><p><b>derivedFrom</b>: <a href=\"DocumentReference-doc-gene-min.html\">DocumentReference: status = current</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://example.org/CodeSystem/genomic-observation-type-cs msiScore}\">MSI Score</span></p><p><b>value</b>: 30 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81695-9}\">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA26203-2}\">MSI-H</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>value</b>: 10 Muts/Mb</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 94077-5}\">Tumor mutation burden [Interpretation]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9194-7}\">Low</span></p></blockquote></div>"
  },
  "status" : "final",
  "code" : {
    "coding" : [
      {
        "system" : "http://example.org/CodeSystem/genomic-observation-type-cs",
        "code" : "biomarker"
      }
    ]
  },
  "subject" : {
    🔗 "reference" : "Patient/pat-min"
  },
  "effectiveDateTime" : "2024-01-01",
  "note" : [
    {
      "text" : "HRD (Homologous Recombination Deficiency)-high HLA LOH (Human Leukocyte Antigen Loss of Heterozygosity) -HLA-A loss"
    }
  ],
  "specimen" : {
    🔗 "reference" : "Specimen/spe-bld-min"
  },
  "device" : {
    🔗 "reference" : "Device/dev-min"
  },
  "derivedFrom" : [
    {
      🔗 "reference" : "DocumentReference/doc-gene-min"
    }
  ],
  "component" : [
    {
      "code" : {
        "coding" : [
          {
            "system" : "http://example.org/CodeSystem/genomic-observation-type-cs",
            "code" : "msiScore"
          }
        ]
      },
      "valueQuantity" : {
        "value" : 30,
        "unit" : "%",
        "system" : "http://unitsofmeasure.org",
        "code" : "%"
      }
    },
    {
      "code" : {
        "coding" : [
          {
            "system" : "http://loinc.org",
            "code" : "81695-9"
          }
        ]
      },
      "valueCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://loinc.org",
            "code" : "LA26203-2"
          }
        ],
        "text" : "MSI-H"
      }
    },
    {
      "code" : {
        "coding" : [
          {
            "system" : "http://loinc.org",
            "code" : "94076-7"
          }
        ]
      },
      "valueQuantity" : {
        "value" : 10,
        "unit" : "Muts/Mb"
      }
    },
    {
      "code" : {
        "coding" : [
          {
            "system" : "http://loinc.org",
            "code" : "94077-5"
          }
        ]
      },
      "valueCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://loinc.org",
            "code" : "LA9194-7"
          }
        ],
        "text" : "Low"
      }
    }
  ]
}