<?xml version="1.0" encoding="UTF-8"?>

<Observation xmlns="http://hl7.org/fhir">
  <id value="obs-biomarker-min"/>
  <meta>
    <profile value="http://example.org/StructureDefinition/Observation-biomarker-twngs"/>
  </meta>
  <text>
    <status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Observation obs-biomarker-min</b></p><a name="obs-biomarker-min"> </a><a name="hcobs-biomarker-min"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-Observation-biomarker-twngs.html">基因生物標記資訊-Observation Biomarker TWNGS</a></p></div><p><b>status</b>: Final</p><p><b>code</b>: <span title="Codes:{http://example.org/CodeSystem/genomic-observation-type-cs biomarker}">Biomarker</span></p><p><b>subject</b>: <a href="Patient-pat-min.html">王大明 Male, DoB: 2001-01-01 ( Medical record number (use: official, ))</a></p><p><b>effective</b>: 2024-01-01</p><p><b>note</b>: </p><blockquote><div><p>HRD (Homologous Recombination Deficiency)-high HLA LOH (Human Leukocyte Antigen Loss of Heterozygosity) -HLA-A loss</p>
</div></blockquote><p><b>specimen</b>: <a href="Specimen-spe-bld-min.html">Specimen: identifier = 123-4567; type = Bld</a></p><p><b>device</b>: <a href="Device-dev-min.html">Device: modelNumber = HiSeq 4000 System</a></p><p><b>derivedFrom</b>: <a href="DocumentReference-doc-gene-min.html">DocumentReference: status = current</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://example.org/CodeSystem/genomic-observation-type-cs msiScore}">MSI Score</span></p><p><b>value</b>: 30 %<span style="background: LightGoldenRodYellow"> (Details: UCUM  code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 81695-9}">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA26203-2}">MSI-H</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 94076-7}">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>value</b>: 10 Muts/Mb</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 94077-5}">Tumor mutation burden [Interpretation]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9194-7}">Low</span></p></blockquote></div>
  </text>
  <status value="final"/>
  <code>
    <coding>
      <system value="http://example.org/CodeSystem/genomic-observation-type-cs"/>
      <code value="biomarker"/>
    </coding>
  </code>
  <subject>
    <reference value="Patient/pat-min"/>
  </subject>
  <effectiveDateTime value="2024-01-01"/>
  <note>
    <text value="HRD (Homologous Recombination Deficiency)-high HLA LOH (Human Leukocyte Antigen Loss of Heterozygosity) -HLA-A loss"/>
  </note>
  <specimen>
    <reference value="Specimen/spe-bld-min"/>
  </specimen>
  <device>
    <reference value="Device/dev-min"/>
  </device>
  <derivedFrom>
    <reference value="DocumentReference/doc-gene-min"/>
  </derivedFrom>
  <component>
    <code>
      <coding>
        <system value="http://example.org/CodeSystem/genomic-observation-type-cs"/>
        <code value="msiScore"/>
      </coding>
    </code>
    <valueQuantity>
      <value value="30"/>
      <unit value="%"/>
      <system value="http://unitsofmeasure.org"/>
      <code value="%"/>
    </valueQuantity>
  </component>
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="81695-9"/>
      </coding>
    </code>
    <valueCodeableConcept>
      <coding>
        <system value="http://loinc.org"/>
        <code value="LA26203-2"/>
      </coding>
      <text value="MSI-H"/>
    </valueCodeableConcept>
  </component>
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="94076-7"/>
      </coding>
    </code>
    <valueQuantity>
      <value value="10"/>
      <unit value="Muts/Mb"/>
    </valueQuantity>
  </component>
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="94077-5"/>
      </coding>
    </code>
    <valueCodeableConcept>
      <coding>
        <system value="http://loinc.org"/>
        <code value="LA9194-7"/>
      </coding>
      <text value="Low"/>
    </valueCodeableConcept>
  </component>
</Observation>